botox - Uma visão geral
botox - Uma visão geral
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Patients should be considered for reinjection when the clinical effect of the previous injection has diminished (median time until patients qualified for the second treatment of BOTOX in double-blind, placebo-controlled clinical studies was 169 days [~24 weeks]), but no sooner than 12 weeks from the prior bladder injection.
Postmarketing safety data from BOTOX and other approved botulinum toxins suggest that botulinum toxin effects may, in some cases, be observed beyond the sitio of local injection. The symptoms are consistent with the mechanism of action of botulinum toxin and may include asthenia, generalized muscle weakness, diplopia, ptosis, dysphagia, dysphonia, dysarthria, urinary incontinence, and breathing difficulties. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening and there have been reports of death related to spread of toxin effects.
Repeat injections for hyperhidrosis should be administered when the clinical effect of a previous injection diminishes.
Botox and Botox Cosmetic are purified forms of botulinum toxin that when injected in tiny, controlled doses are very safe and effective at relaxing excessive muscle contraction, even though ingestion of food contaminated with C. botulinum causes botulism - an often fatal, paralytic-type illness.
While Botox is generally considered safe when administered by a qualified professional, higher doses might potentially increase the risk or severity of common side effects like bruising, swelling, or headaches at the injection site.
This is because each manufacturer uses assay methods specific to their company, so even though dosages may be quoted in similar-sounding units, potency can vary several-fold between the different products. Care needs to be taken that the correct dosage stated is used for that particular product and the approved indications for the different products also vary.
to prevent headaches in people with migraine who have 14 or fewer headache days each month (episodic migraine)
Adult Detrusor Overactivity associated with a Neurologic Condition In two double-blind, placebo-controlled trials in adult patients with detrusor overactivity associated with a neurologic condition (NDO-1 and NDO-2), the proportion of subjects who were not using clean intermittent catheterization (CIC) prior to injection and who subsequently required catheterization for urinary retention following treatment with BOTOX 200 Units or placebo is shown in Table 12.
Do not start any new medicines until you have told your doctor that you have received onabotulinumtoxinA in the past. Especially tell your doctor if you:
RADIESSE® and RADIESSE® (+) are dermal fillers that are used for smoothing moderate to severe facial wrinkles and folds, such as nasolabial folds (the creases that extend from the corner of your nose to liftera the corner of your mouth).
Previous Botox History: If you've had Botox before, your injector will consider how you responded to previous treatments. Did the standard dose work well? Did it wear off quickly? Did you need a touch-up? This history helps refine the dosage for subsequent sessions.
Tell your health care provider if you are taking blood thinners or medicines that can interfere with the clotting of blood, such as aspirin or warfarin. These medicines might make it more likely that you will experience bruising or bleeding at the injection site.
Reconstituted BOTOX should be clear, colorless, and free of particulate matter. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration and whenever the solution and the container permit.
Injection into the dorsum of the hand may cause adverse events that last for more than 14 days, and may result in temporary difficulty performing activities (48% of study patients reported this adverse event).